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Day 100 Post Transplant

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Next Topic: Chronic graft versus host disease (cGVHD)

Around day 100 your care team will assess how your body is healing and begin discussing next steps after your transplant such as decreasing immune suppression, considering central line removal, possibly decreasing restrictions.

What happens around day 100

  • Central Line Discussion: If your recovery is stable and labs are manageable; your team may consider removing your central line

  • Immune Reconstitution: Blood tests will show how your immune system is rebuilding; this guides decisions about exposure risks and future care

  • Weaning Immunosuppression: If there is no sign of GVHD your provider may begin tapering medications

  • Vaccination Planning: You’ll discuss when to restart vaccines, which typically begins around 6–12 months post-transplant depending on your immune status

What I Wish I Knew

  • Medication intolerance can emerge as doses change—report side effects early

  • Small symptoms matter—even subtle changes can signal immune shifts

  • Rebuilding immunity takes time, and vaccine schedules vary based on GVHD and immunosuppression

  • Emotional recovery is just as important—ask for support if you’re feeling isolated or overwhelmed

Questions to Ask

  • When can I start vaccines again, and which ones come first?

  • What signs show that my immune system is recovering?

  • Will I need labs or imaging before removing my central line?

  • How will we taper immunosuppressants, and what symptoms should I watch for?

Common Myths

Myth: Many things will happen at day 100

Fact: “Nothing really happens on Day 100” - it is just a time point where your team reviews progress and makes more decisions – physically and mentally you do not really feel that different

Helpful Tips

  • Talk with schools – If you have children, help educators understand your family’s health precautions

  • Expect continued isolation – Your immune system is still fragile; precautions remain important

  • You’ll still be on medications – Immunosuppressants, antivirals, and other meds may continue for months

  • Find gentle distractions – Car rides, short walks, or creative hobbies can help ease the emotional weight

Next Topic: Chronic graft versus host disease (cGVHD)

Disclaimer: This Journey Map is for educational purposes only. It does not provide medical advice, diagnosis, or treatment. Every patient’s situation is unique, and care decisions should always be made in consultation with your clinical team.

We extend our appreciation to Sanofi and Alexion for their generous partnership and active participation in our community. Their support helped bring patients, caregivers, clinicians, and industry partners together to co-create this Journey Map and improve the transplant experience.

Our Journey Map was created for Patients and Caregivers by Patients and Caregivers. Please share any corrections or additions!