Chronic Graft versus host disease (cGVHD)
Chronic Graft-Versus-Host Disease (GVHD) is GVHD that developes later on after stem cell transplant, usually 100 days after and it is considered a long-term complication. It occurs when the donor’s immune cells attack the recipient's body tissues, affecting organs like the skin, GI tract, lungs, liver, and eyes.
Treatment includes immunosuppressive therapies and lifestyle modifications.
By understanding the impact of chronic GVHD and engaging in proactive care, patients can better navigate this complex aspect of transplant recovery.
Why is it considered “Chronic”
Timing: Chronic GVHD usually develops after the first 100 days post-transplant, but onset can vary.
Duration: Unlike acute GVHD, which may resolve quickly with treatment, chronic GVHD often persists for months or years, and in some cases, becomes a lifelong condition.
Symptoms: Chronic GVHD can resemble autoimmune diseases, with slow-developing symptoms and multi-organ involvement.
Complexity: It often requires long-term immunosuppression, lifestyle adjustments, and coordinated care across specialties.
Disclaimer: This Journey Map is for educational purposes only. It does not provide medical advice, diagnosis, or treatment. Every patient’s situation is unique, and care decisions should always be made in consultation with your clinical team.
We extend our appreciation to Sanofi and Alexion for their generous partnership and active participation in our community. Their support helped bring patients, caregivers, clinicians, and industry partners together to co-create this Journey Map and improve the transplant experience.
Our Journey Map was created for Patients and Caregivers by Patients and Caregivers. Please share any corrections or additions!