Catching the First Whispers: Advancing Early Diagnosis of Chronic GVHD

📖 Episode Description:
In this episode, we explore the critical challenge of recognizing chronic graft-versus-host disease (cGVHD) at its earliest signs—before irreversible damage occurs. Using the 2020 NIH Clinical Implementation and Early Diagnosis Working Group Report as our guide, we discuss how simple, practical steps can make a real difference in detecting cGVHD sooner and improving patient outcomes.

You’ll learn:

  • Why even with improved diagnostic criteria, delays in diagnosis still happen—and why that matters.

  • How healthcare providers can take immediate action by:

    • Improving education for both transplant specialists and community care teams.

    • Using a pre-transplant checklist to document baseline health and recognize new symptoms.

    • Scheduling regular follow-ups and knowing when to refer patients back to transplant centers.

  • The important role patients and caregivers play in early detection—learning what subtle signs to watch for and how to report them effectively.

  • Why early reporting and regular monitoring help clinicians intervene before cGVHD causes serious long-term complications.

This episode is all about empowering both clinicians and patients to take meaningful steps today—because catching cGVHD earlier can truly change lives.

Sources:

National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: IIa. The 2020 Clinical Implementation and Early Diagnosis Working Group Report

Kitko, Carrie L., et al. "National Institutes of Health consensus development project on criteria for clinical trials in chronic graft-versus-host disease: IIa. The 2020 clinical implementation and early diagnosis working group report." Transplantation and cellular therapy 27.7 (2021): 545-557.