Begin Chemotherapy and/or Radiation
Patients usually receive chemotherapy and/or radiation before the transplant, which prepares the body to receive new cells.
There are a few different types of regimens, and your care team will decide which one is best for you.
Different types of regimens:
Myeloablative (high intensity) – uses strong doses of chemotherapy to remove of all bone marrow cells
Reduced-intensity (RIC) – uses lower doses that are less toxic, often for older or medically fragile patients
Non-myeloablative – minimal intensity, relying more on the donor’s immune system to provide a new immune system.
What Is Chemotherapy?
It is given before the stem cells to prepare the bone marrow for the new cells.
Why It Matters:
Eliminate diseased/cancer cells
Eliminates immune system cells
It makes room for new stem cells to grow
It reduces the risk of transplant rejection
Tips for Chemo Prep
Ask your team what side effects to expect and how to manage them (next step has more info)
Stay hydrated and eat what you can—nutritional support is available
Bring comfort items for long infusion days (books, music, snacks)
Use a calendar or app to track medications and appointments
Questions to Ask Your Care Team
What type of preparative regimen will I receive?
How does it compare to what other patients receive?
What are the short- and long-term side effects?
What should I expect during chemotherapy or radiation?
How can I prepare emotionally and physically?
What support is available for my caregiver?
Infection Prevention
Wash hands frequently and avoid crowds
Wear a mask if recommended by your team
Keep your central line clean and follow care instructions
Report any fever, chills, or signs of infection immediately
Disclaimer: This Journey Map is for educational purposes only. It does not provide medical advice, diagnosis, or treatment. Every patient’s situation is unique, and care decisions should always be made in consultation with your clinical team.
We extend our appreciation to Sanofi and Alexion for their generous partnership and active participation in our community. Their support helped bring patients, caregivers, clinicians, and industry partners together to co-create this Journey Map and improve the transplant experience.
Our Journey Map was created for Patients and Caregivers by Patients and Caregivers. Please share any corrections or additions!